Table 2.
Characteristics of resected hepatocellular carcinoma specimens according to elevations of conventional or highly sensitive AFP-L3 after hepatectomy (n = 187)
| Conventional AFP-L3 | Highly sensitive AFP-L3 | |||
|---|---|---|---|---|
| Negative (n = 174) | Positive (n = 13) | Negative (n = 89) | Positive (n = 98) | |
| Child-Pugh class (A/B) | 166 (95.4)/8 (4.6) | 13 (100)/0 | 87 (97.8)/2 (2.2) | 92 (93.9)/6 (6.1) |
| Tumor size (cm) | 3.09 ± 2.30a | 5.19 ± 4.21a | 3.28 ± 2.56 | 3.20 ± 2.50 |
| Number of tumors (single/multiple) | 143 (82.2)/31 (17.8) | 10 (76.9)/3 (23.1) | 73 (82.0)/16 (18.0) | 80 (81.6)/18 (18.4) |
| Differentiation (well-/moderately or poorly) | 52 (29.9)/122 (70.1)2 | 0/13 (100)b | 25 (29.1)/64 (71.9) | 27 (27.6)/71 (72.4) |
| Growth pattern (expansive/infiltrative) | 161 (92.5)/13 (7.5)c | 9 (69.2)/4 (30.8)c | 81 (91.0)/8 (9.0) | 89 (90.8)/9 (9.2) |
| Capsular formation (absent/present)1 | 62 (38.5)/99 (61.5) | 2 (22.2)/7 (77.8) | 28 (34.6)/53 (65.4) | 36 (40.4)/53 (59.6) |
| Capsular infiltration (absent/present)2 | 38 (38.4)/61 (61.6) | 1 (14.3)/6 (85.7) | 23 (43.4)/30 (56.6) | 16 (30.2)/37 (69.8) |
| Portal vein invasion (absent/present)3 | 146 (83.9)/28 (16.1) | 8 (61.5)/5 (38.5) | 69 (77.5)/20 (22.5) | 85 (86.7)/13 (13.3) |
Unless otherwise indicated, values are means ± SD and percentages are indicated in parentheses. aP = 0.0143, bP = 0.0454, cP = 0.0203.
1
Evaluated only in HCC with expansive growth.
2
Evaluated only in HCC with capsular formation.
3
On pathologic evaluation.