Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Effect of EGFR signaling on IRF1-induced CXCL10 production. Top, respiratory viruses (e.g., influenza virus, RV, and RSV) stimulate airway epithelial NADPH oxidase (Nox), metalloproteinase (MP), and ligand-induced activation of EGFR, which leads to IL-8 production. EGFR activation suppresses IRF1-induced CXCL10. Bottom, in the presence of EGFR inhibition (e.g., gefitinib and AG-1478), IRF1-induced CXCL10 is increased.
