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. Author manuscript; available in PMC: 2015 Jul 8.
Published in final edited form as: Tetrahedron. 2014 Mar 12;70(27-28):4156–4164. doi: 10.1016/j.tet.2014.03.009

Figure 3.

Figure 3

Identification of candidate diazo-forming enzymes and potential involvement in fluostatin biosynthesis. (A) Genes encoding putative diazo-forming enzymes and their distribution in characterized natural product biosynthetic gene clusters. (B) Structure of hydrazide-containing natural product fosfazinomycin A. (C) Structures of the fluostatins isolated from heterologous expression of BAC AB649/1850. (D) Biosynthetic hypothesis for formation of the fluostatins from diazo-containing precursors.