Table 3.

Multivariable analysis of cell markers and disease free survival (DFS)

Variables	HR (95% CI)	p-value
Tumor regression grade 1	1	0.046
Tumor regression grade 2	0.257 (0.079,0.853)	0.024
Tumor regression grade 3	0.065 (0.007,0.604)	0.016
Tumor regression grade 4*	<0.001 (NA).	0.999
ypN0	1	0.001
ypN1	9.025 (2.276,35.792)	0.002
ypN2	15.542 (3.634,66.462)	0.001
CD166	5.614 (1.816,17.356)	0.003
p21	6.146 (2.035,18.559)	0.001

*No event (disease recurrence) was observed.