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. 2014 Feb 28;14:8. doi: 10.1186/1471-213X-14-8

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Copyright © 2014 Motch Perrine et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Skull morphology of Fgfr2^+/P253Rand Fgfr2^+/S252WApert syndrome mice and unaffected littermates at E17.5 and P0. Left lateral views of 3D HRμCT reconstructions of representative mice from our study samples: Fgfr2^+/P253R mutant at E17.5 (A) and P0 (B): unaffected littermate of the P253R model at E17.5 (C) and P0 (D); Fgfr2^+/S252W mutant at E17.5 (E) and P0 (F); unaffected littermate of the S252W model at E17.5 (G) and P0 (H). By P0, midfacial retrusion is more severe and fusion of multiple sutures is apparent.