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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Brain Behav Immun. 2014 Jan 11;39:121–129. doi: 10.1016/j.bbi.2014.01.003

Table 3. microRNAs in monocytes significantly affected by exercise and their possible connection to atherosclerosis.

microRNA Fold Change p-value FDR Possible link to atherosclerosis
miR-199a-3p ↓1.5 0.044 Unknown
miR-130a ↓1.5 0.044 Involved in angiogenesis in endothelial progenitor cells (Zhang, Kandic, and Kutryk, 2011).
miR-151-5p ↓1.4 0.044 Unknown
miR-221 ↓1.3 0.042 Involved in vascular remodeling (Wei, Schober, and Weber, 2013); regulation of monocytes into dendritic cells (Lu, Huang, Zhang, Roensch, Cao, Nakayama, Blazar, Zeng, and Zhou, 2011).
miR-23b ↓1.3 0.044 Plays an atheroprotective role in shear stress vascular remodeling (Neth, Nazari-Jahantigh, Schober, and Weber, 2013).
miR-29b ↑1.9 0.044 Plays a key role in the mechanisms through which LDLs alter vascular smooth muscle function (Chen, Wang, Hu, Chang, Liao, Dai, and Juo, 2011); significantly upregulated in atherosclerotic aortic aneurysm tissue (Kin, Miyagawa, Fukushima, Shirakawa, Torikai, Shimamura, Daimon, Kawahara, Kuratani, and Sawa, 2012).
miR-29c ↑1.5 0.043 Unknown
miR-1305 ↑1.5 0.028 Unknown
miR-362-3p ↑1.4 0.044 Downregulated more than twofold in both brain and blood following experimental injury to the cerebral vasculature (Liu, Tian, Ander, Xu, Stamova, Zhan, Turner, Jickling, and Sharp, 2010).
miR-660 ↑1.4 0.028 Increase the efficiency of ex vivo platelet generation (Emmrich, Henke, Hegermann, Ochs, Reinhardt, and Klusmann, 2012).
miR-324-3p ↑1.4 0.035 Unknown
miR-1202 ↑1.3 0.044 Unknown
miR-140-5p ↑1.3 0.028 Circulating levels are elevated in severely obese individuals (Ortega, Mercader, Catalan, Moreno-Navarrete, Pueyo, Sabater, Gomez-Ambrosi, Anglada, Fernandez-Formoso, Ricart, Fruhbeck, and Fernandez-Real, 2013).
miR-532-5p ↑1.3 0.028 Circulating levels are elevated in severely obese individuals (Ortega et al., 2013).
miR-362-5p ↑1.3 0.028 Unknown
miR-30e ↑1.3 0.044 Substantially downregulated in animal model of atherosclerotic lesions (Han, Wang, Qu, Sun, Li, Jiang, and Luo, 2013).
miR-532-3p ↑1.3 0.044 Unknown
miR-15a ↑1.3 0.030 Involved in blood brain barrier disruption in animal models of vascular injury (Rink and Khanna, 2011).
miR-338-3p ↑1.3 0.033 Unknown