Fig. 3. In vivo potential of hPSC-derived lung and airway progenitors.
(a) Representative examples of H&E stains of growths removed 6 months after transplantation of RUES2 cells differentiated according to the protocol shown in Fig. 1b, under the kidney capsule of NSG mice (BC: basal cell; Ca: cartilage; CC: Clara cell; Ci: ciliated cell; GC: goblet cell; Ki: mouse kidney; PSE: pseudostratified epithelium; SM: smooth muscle; SMG: submucosal glands). (b) Representative examples of the expression of markers of mature lung and airway epithelial cells in the growths from (a). Representative of 4 animals.
