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. 2014 Jul 3;2014:315470. doi: 10.1155/2014/315470

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Copyright © 2014 R. Wang and Y.-J. Zhang.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Interference with type I IFN-activated JAK/STAT signaling pathway and antiviral ISGs. IFN-α/-β binds to their receptors IFNAR-1 and IFNAR-2 on cell membrane, which activates JAK/STAT pathway. “P” besides STAT1 and STAT2 indicates phosphorylation. PRRSV nsp1β inhibits ISGF3 nuclear translocation via inducing degradation of KPNA1, which is essential for mediating the nuclear import of ISGF3. N protein also inhibits ISGF3 nuclear translocation. And nsp2 reduces ISG15 production and conjugation via its deubiquitination activity.