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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Nat Struct Mol Biol. 2014 Jan 5;21(2):143–151. doi: 10.1038/nsmb.2740

Figure 7.

Figure 7

Schematic model of EttA function based on the results presented here and in the companion paper30. In the presence of ADP, EttA inhibits formation of the first peptide bound (Fig. 5b), which may be mediated by stabilization of the 70S IC in a hibernating state by ADP-bound EttA. (See Discussion). In contrast, ATP-bound EttA stimulates the formation of the first peptide bond by the ribosome and then, concomitantly with ATP hydrolysis, dissociates from the ribosome, thereby allowing it to enter the elongation cycle.