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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Antiviral Res. 2014 May 14;108:1–9. doi: 10.1016/j.antiviral.2014.05.004

Figure 1.

Figure 1

Disease parameters of mice infected with the S27 strain of CHIKV. A) The effect of CHIKV infection on the time course of footpad swelling of DBA/1J mice at the site of virus challenge when compared to contralateral footpad. B) Time-course of virus in serum, spleen, right hind leg, and left hind leg of DBA/1J mice infected with CHIKV. Viral titer is plotted as 50% cell culture infectious dose (CCID50) per gram of tissue or ml of serum. Upper dashed line is the average limit of detection for tissue homogenates and lower line is for serum. C) Comparison of Sham infected and CHIKV infected spleen weights in grams throughout course of infection (***P<0.001, *P<0.05, as compared with sham-infected controls).