Table 3.
Fractional inhibitory concentrations of acetone stem bark extract of A. mearnsii in combination with the different antibiotics.
| Tested bacterial isolates | Fractional inhibitory concentrations (FIC) | |||||||
|---|---|---|---|---|---|---|---|---|
| AMA + Ery | FICI | AMA + Tet | FICI | AMA + Met | FICI | AMA + Amx | FICI | |
| mg/mL + µg/mL | mg/mL + µg/mL | mg/mL + µg/mL | mg/mL + µg/mL | |||||
| Escherichia coli ATCC 25922 | 0.625/6.25 | 17.00Ant | 0.0098/0.244 | 0.266 Syn | 0.313/15.625 | 1.00 Add | 0.156/7.813 | 1.25 Ind |
| Bacillus cereus ATCC 10702 | 0.0098/0.098 | 1.63 Ind | 0.00122/0.061 | 0.258 Syn | 0.156/7.813 | 1.25 Ind | 0.078/3.906 | 1.000 Add |
| Pseudomonas aeruginosa ATCC 19582 | 0.0049/0.049 | 0.06 Syn | 0.00122/0.061 | 0.133 Syn | 0.625/31.250 | 6.00 Ant | 0.039/1.953 | 0.750 Add |
| Serratia marcescens ATCC 9986 | 0.625/6.25 | 3.00 Ind | 0.0781/3.906 | 0.37 Syn | 0.625/31.250 | 2.00 Ind | 0.156/7.813 | 0.500 Syn |
| Enterococcus faecalis KZN | 0.156/1.563 | 0.38 Syn | 0.313/15.625 | 1.5 Ind | 0.625/31.250 | 1.50 Ind | 0.0049/0.244 | 0.258 Syn |
| Staphylococcus aureus OK1 | 0.0049/0.049 | 0.31 Syn | 0.0098/0.244 | 0.375 Syn | 0.625/31.250 | 10.00 Ant | 0.0049/0.244 | 0.312 Syn |
| Salmonella typhi ATCC 13311 | 0.1563/1.953 | 0.81Add | 0.00122/0.061 | 0.254 Syn | 0.625/31.250 | 3.00 Ind | 0.0049/0.244 | 0.265 Syn |
| Micrococcus luteus | 0.0391/0.391 | 2.00 Ind | 0.0781/3.906 | 2.128 Ind | 0.313/15.625 | 10.00 Ant | 0.0024/0.122 | 0.312 Syn |
| Proteus vulgaris CSIR 0030 | ≤0.0003/0.003 | 0.08 Syn | 0.0049/0.122 | 0.281 syn | 0.078/3.906 | 0.50 Syn | 0.006/0.030 | 0.165 Syn |
| Shigella flexneri KZN | 0.0098/0.098 | 0.38 Syn | 0.156/7.813 | 18.01 Ant | 0.313/15.625 | 4.25 Ant | 0.0391/1.953 | 0.509 Add |
|
| ||||||||
| Tested bacterial isolates | Fractional inhibitory concentrations (FIC) | |||||||
| AMA + Cip | FICI | AMA + Nal | FICI | AMA + Chl | FICI | AMA + Kan | FICI | |
| mg/mL + µg/mL | mg/mL + µg/mL | mg/mL + µg/mL | mg/mL + µg/mL | |||||
|
| ||||||||
| Escherichia coli ATCC 25922 | 0.0098/0.0098 | 0.266 Syn | 0.078/3.906 | 2.125 Ind | 0.0391/1.953 | 0.563 Add | 0.156/7.813 | 0.313 Syn |
| Bacillus cereus ATCC 10702 | 0.0781/0.0781 | 1.500 Ind | 0.313/15.625 | 3.000 Ind | 0.0195/0.977 | 0.375 Syn | 0.078/3.906 | 0.531 Add |
| Pseudomonas aeruginosa ATCC 19582 | 0.0781/0.0781 | 1.000 Add | 0.156/7.813 | 2.000 Ind | 0.0195/0.977 | 0.375 Syn | 0.0391/1.953 | 0.312 Syn |
| Serratia marcescens ATCC 9986 | 0.0098/0.0098 | 0.250 Syn | 0.039/1.953 | 1.062 Ind | 0.0098/0.488 | 0.512 Add | 0.078/3.906 | 2.125 Ind |
| Enterococcus faecalis KZN | 1.25/1.25 | 6.000 Ant | 0.625/31.250 | 1.500 Ind | 0.0781/3.906 | 0.250 Syn | 1.250/62.500 | 2.125 Ind |
| Staphylococcus aureus OK1 | 0.0098/0.0098 | 0.251 Syn | 0.156/7.813 | 2.125 Ind | 0.0391/1.953 | 0.750 Add | 0.313/15.625 | 5.000 Ant |
| Salmonella typhi ATCC 13311 | 0.0049/0.0049 | 0.27 Syn | 0.039/1.953 | 0.37 Syn | 0.0195/0.977 | 0.44 Syn | 0.0097/0.488 | 0.062 Syn |
| Micrococcus luteus | 0.3125/0.3125 | 8.250 Ant | 0.156/7.813 | 4.125 Ant | 0.0391/1.953 | 2.000 Ind | 0.625/31.500 | 16.13 Ant |
| Proteus vulgaris CSIR 0030 | 0.0049/0.0049 | 0.283 Syn | 0.078/3.906 | 0.562 Add | 0.0781/3.906 | 0.626 Add | 0.0391/1.953 | 0.312 Syn |
| Shigella flexneri KZN | 0.0098/0.0098 | 0.377 Syn | 0.313/15.625 | 4.250 Ant | 0.0391/1.953 | 0.750 Add | 0.313/15.625 | 5.000 Ant |
AMA: acetone extract of A. mearnsii; Ery: erythromycin; Tet: tetracycline; Met: metronidazole; Cip: ciprofloxacin; Nal: nalidixic acid; Chl: chloramphenicol; Kan: kanamycin; FICI: fractional inhibitory concentration indices.