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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Trends Biochem Sci. 2013 Feb 7;38(3):160–167. doi: 10.1016/j.tibs.2012.12.004

Figure 1. The enzymatic reaction catalyzed by Sirt1.

Figure 1

Sirt1 catalyzes the deacetylation of several proteins by consuming nicotinamide adenine dinucleotide (NAD+), generating nicotinamide (NAM) and 2′-O-Acetyl-ADP-Ribose. NAM is recycled back into NAD+ by the enzymes nicotinamide phosphorybosyltransferase (NAMPT), nicotinamide mononucleotide adenylyltransferase (NMNAT), and the nicotinamide mononucleotide (NMN) intermediate.