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In a low energy state, several transcription factors, like CREB (cyclic AMP response-element-binding protein), FOXO1 (forkhead box O1), FOXO3A, PPARα (Peroxisome proliferator-activated receptors alpha), and PPARβ/σ, can increase and the expression of Sirt1; in a high energy state, ChREBP (carbohydrate response-element-binding protein), PPARγ, and HIC1 (hypermethylated in cancer protein 1) can repress Sirt1 expression.
