Table 1.
Pearson product-moment correlation coefficients (bottom left) and ratios of the root-mean-square differences to the averages (top right) between quantification methods of measuring DAT availabilities.
| Method | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (1) MRI-delineation | — | 57% | 33% | 35% | 30% | 26% | 21% | 17% | 15% | 16% | 43% | 31% | 23% | 25% | 30% | 17% | 19% | 17% |
| (2) SPECT-delineation | 0.56 | — | 32% | 83% | 79% | 75% | 70% | 65% | 59% | 53% | 32% | 40% | 61% | 59% | 35% | 48% | 70% | 67% |
| (3) Template-ROI | 0.79 | 0.65 | — | 62% | 57% | 52% | 47% | 42% | 36% | 30% | 23% | 23% | 40% | 38% | 14% | 23% | 46% | 43% |
| (4) 90% Threshold-ROI | 0.74 | 0.50 | 0.70 | — | 5% | 11% | 17% | 23% | 30% | 37% | 71% | 59% | 40% | 43% | 59% | 44% | 21% | 24% |
| (5) 85% Threshold-ROI | 0.74 | 0.50 | 0.70 | 1.00 | — | 6% | 11% | 18% | 25% | 32% | 66% | 54% | 36% | 39% | 54% | 39% | 17% | 19% |
| (6) 80% Threshold-ROI | 0.74 | 0.50 | 0.71 | 1.00 | 1.00 | — | 6% | 12% | 19% | 26% | 61% | 50% | 32% | 35% | 49% | 34% | 13% | 15% |
| (7) 75% Threshold-ROI | 0.74 | 0.51 | 0.71 | 1.00 | 1.00 | 1.00 | — | 6% | 13% | 21% | 56% | 45% | 28% | 31% | 44% | 29% | 12% | 12% |
| (8) 70% Threshold-ROI | 0.75 | 0.51 | 0.72 | 1.00 | 1.00 | 1.00 | 1.00 | — | 7% | 14% | 51% | 39% | 25% | 28% | 38% | 23% | 13% | 12% |
| (9) 65% Threshold-ROI | 0.75 | 0.51 | 0.72 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | — | 7% | 45% | 34% | 24% | 25% | 31% | 18% | 17% | 15% |
| (10) 60% Threshold-ROI | 0.76 | 0.52 | 0.73 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | — | 38% | 28% | 24% | 25% | 25% | 13% | 23% | 20% |
| (11) MRI-normalization | 0.78 | 0.55 | 0.70 | 0.74 | 0.74 | 0.74 | 0.74 | 0.75 | 0.75 | 0.75 | — | 14% | 39% | 36% | 18% | 31% | 55% | 51% |
| (12) MRI-norm., VC | 0.78 | 0.55 | 0.70 | 0.73 | 0.73 | 0.73 | 0.74 | 0.74 | 0.75 | 0.75 | 1.00 | — | 26% | 23% | 15% | 21% | 43% | 39% |
| (13) MRI-norm., GTM | 0.75 | 0.52 | 0.68 | 0.71 | 0.71 | 0.71 | 0.71 | 0.72 | 0.73 | 0.73 | 0.99 | 0.99 | — | 4% | 34% | 23% | 25% | 23% |
| (14) MRI-norm., RBV | 0.74 | 0.51 | 0.67 | 0.71 | 0.71 | 0.71 | 0.71 | 0.72 | 0.73 | 0.73 | 0.99 | 0.99 | 1.00 | — | 32% | 22% | 28% | 26% |
| (15) SPECT-norm. | 0.83 | 0.54 | 0.76 | 0.85 | 0.85 | 0.85 | 0.85 | 0.86 | 0.86 | 0.87 | 0.91 | 0.91 | 0.89 | 0.88 | — | 16% | 42% | 38% |
| (16) SPECT-norm., VC | 0.82 | 0.52 | 0.75 | 0.85 | 0.85 | 0.85 | 0.85 | 0.86 | 0.86 | 0.87 | 0.88 | 0.88 | 0.86 | 0.86 | 1.00 | — | 26% | 23% |
| (17) SPECT-norm., GTM | 0.80 | 0.47 | 0.74 | 0.84 | 0.84 | 0.84 | 0.84 | 0.85 | 0.85 | 0.85 | 0.84 | 0.85 | 0.83 | 0.82 | 0.98 | 0.99 | — | 4% |
| (18) SPECT-norm., RBV | 0.80 | 0.47 | 0.73 | 0.84 | 0.85 | 0.85 | 0.85 | 0.86 | 0.86 | 0.86 | 0.86 | 0.86 | 0.85 | 0.84 | 0.98 | 0.99 | 1.00 | — |
DAT: dopamine transporter; MRI: magnetic resonance imaging; SPECT: single photon emission-computed tomography; ROI: region of interest; norm.: normalization; GTM: geometric transfer matrix; RBV: region-based voxel-wise; VC: Van-Cittert deconvolution.