Table 8.
Drug/molecule | Mechanism of action | Phase/used in combination with other agents |
---|---|---|
DZNep inhibitor | Disruption of PRC2 | Preclinical |
Vimodegib (GDC-0449) | Hedgehog signaling inhibitor | Phase I/after auto SCT |
R0490927 | NOTCH signaling inhibitor | Phase II/melphalan |
MK571 | MRP3 inhibitor | Preclinical/bortezomib |
ATRA | Induces degradation of RARα2 | Preclinical |
Imetelstat | Telomerase Inhibitor | Preclinical |
NK cell therapy | Cellular cytotoxicity | Preclinical |
SCT = Stem cell transplant.