Table 2.
Indices of Bone and Mineral Metabolism and Markers of Formation and Resorption in Women with Epilepsy on AED Monotherapy Grouped by AED Treatment
| PHT | CBZ | VPA | LTG | |
|---|---|---|---|---|
| Calcium (mg/dl) | 8.9a(8.8–9.1) | 8.9a(8.8–9.0) | 8.9a(8.7–9.1) | 9.2 (9.0–9.3) |
| 25(OH)D (ng/ml) | 20 (14–29) | 21 (18–25) | 25 (18–35) | 30 (24–37) |
| PTH (pg/ml) | 35 (21–60) | 31 (26–36) | 30 (21–43) | 31 (22–43) |
| BSAPb (U/L) | 20.2 (17.2–23.8) | 16.2 (14.8–17.6) | 14.8 (13.0–16.9) | 15.0 (12.9–17.4) |
| Osteocalcin (ng/ml) | 10.3 (6.7–15.6) | 5.3 (3.6–7.8) | 8.8 (5.1–14.9) | 6.7 (4.1–10.7) |
| NTXc (nM/mM creatinine) | 46.4 (30.5–70) | 36.1 (29.4–44.4) | 31.8 (23.1–43.7) | 28.4 (22.7–35.3) |
| IGF-1d (ng/ml) | 142 (75–271) | 266 (214–329) | 179 (107–298) | 357 (251–508) |
| IGFBP-3 (ng/ml) | 2,483 (1,358–4,540) | 3,631 (3,205–4,114) | 3,682 (2,950–4,596) | 4,212 (3,746–4,735) |
| IGF-1/IGFBP-3 | 0.062 | 0.083 | 0.071 | 0.094 |
a
p = 0.03; PHT CBZ VPA lower than LTG.
b
p = 0.007; PHT highest, LTG and VPA low.
c
p = 0.064; AEDs indistinguishable.
d
p = 0.012; LTG highest, PHT lowest.
ep = 0.060; LTG highest, PHT lowest.
AED = antiepileptic drug; BSAP = bone specific alkaline phosphatase; CBZ = carbamazepine; VPA = valproate; LTG = lamotrigine; PTH = parathyroid hormone; NTX = N-telopeptide of type I bone collagen; IGF = insulin growth factor I; IGFBP = IGF binding protein.