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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Methods Mol Biol. 2014;1126:83–96. doi: 10.1007/978-1-62703-980-2_6

Fig. 2.

Fig. 2

Kinetic Model of Cotranscriptional Splicing. (a) In Saccharomyces cerevisiae, RNA Pol II pauses at the terminal exon and/or 3′ SS to facilitate cotranscriptional splicing. (b) RNA Pol II rate of elongation modulates cotranscriptional alternative splicing. Fast elongation rate of transcription (left) favors skipping of exons with “weak” upstream 3′ splice sites (blue exon). Slower Pol II elongation rates (right) favor inclusion of exons with weak 3′ SS sites. Constitutive exons (containing strong 3′ SS) are included independently of RNA Pol II elongation rate (not shown)