Table 1.
Characteristics of study participants
| Variable | Batch 1* | Batch 2* | Batch 3^ | Total |
|---|---|---|---|---|
|
Age at case diagnosis |
|
|
|
|
| N |
69 |
146 |
121 |
336 |
| Mean (SD) |
60.2 (12.0) |
63.3 (12.8) |
62.2 (11.3) |
62.3 (12.1) |
| Range |
(33.0-82.0) |
(28.0-91.0) |
(33.0-86.0) |
(28.0-91.0) |
|
Age at control enrollment |
|
|
|
|
| N |
87 |
176 |
135 |
398 |
| Mean (SD) |
60.2 (12.1) |
62.9 (12.7) |
62.4 (11.4) |
62.2 (12.2) |
| Range |
(33.0-85.0) |
(27.0-89.0) |
(33.0-88.0) |
(27.0-89.0) |
|
EOC case vital status |
|
|
|
|
| Alive |
35 (51%) |
51 (35%) |
59 (49%) |
145 (43%) |
| Deceased |
34 (49%) |
95 (65%) |
62 (51%) |
191 (57%) |
|
Follow-up time (years) |
|
|
|
|
| Mean (SD) |
2.8 (1.5) |
4.1 (2.8) |
3.0 (2.5) |
3.4 (2.5) |
| Range |
(0.1-6.4) |
(0.0-11.0) |
(0.1-11.4) |
(0.0-11.4) |
|
Parity |
|
|
|
|
| Nulliparous |
25 (16%) |
47 (15%) |
34 (13%) |
106 (14%) |
| 1-2 |
49 (32%) |
104 (32%) |
109 (43%) |
262 (36%) |
| 3+ |
77 (50%) |
156 (48%) |
97 (38%) |
331 (45%) |
| Unknown |
4 (2%) |
15 (5%) |
16 (6%) |
35 (5%) |
|
Smoking status |
|
|
|
|
| Never/former |
140 (90%) |
284 (88%) |
213 (83%) |
637 (87%) |
| Current |
10 (6%) |
19 (6%) |
20 (8%) |
49 (7%) |
| Unknown |
6 (4%) |
19 (6%) |
23 (9%) |
48 (7%) |
|
Alcohol use |
|
|
|
|
| Current |
93 (60%) |
172 (53%) |
133 (52%) |
398 (54%) |
| Former |
22 (14%) |
50 (16%) |
47 (18%) |
119 (16%) |
| Never |
34 (22%) |
73 (23%) |
48 (19%) |
155 (21%) |
| Unknown |
7 (5%) |
27 (8%) |
28 (11%) |
62 (8%) |
|
Histology, cases only |
|
|
|
|
| Serous |
46 (66.7%) |
97 (66.4%) |
100 (82.6%) |
243 (72%) |
| Endometrioid |
16 (23.2%) |
32 (22%) |
15 (12%) |
63 (19%) |
| Clear cell |
4 (5.8%) |
9 (6%) |
3 (3%) |
16 (5%) |
| Mucinous |
1 (1.4%) |
4 (3%) |
3 (3%) |
8 (2%) |
| Other |
2 (2.9%) |
4 (3%) |
0 (0%) |
6 (2%) |
|
Grade, cases only |
|
|
|
|
| Grade 1 or 2 |
11 (16%) |
29 (20%) |
16 (13%) |
56 (17%) |
| Grade 3 or 4 |
56 (81%) |
117 (80%) |
103 (85%) |
276 (82%) |
| Unknown |
2 (3%) |
0 (0%) |
2 (2%) |
4 (1%) |
|
Stage, cases only |
|
|
|
|
| Stage I or II |
14 (20%) |
39 (27%) |
21 (17%) |
74 (22%) |
| Stage III or IV |
55 (80%) |
107 (73%) |
100 (83%) |
262 (78%) |
|
Surgical debulking, cases only |
|
|
|
|
| Optimal (<1 cm) |
57 (83%) |
123 (84%) |
105 (87%) |
285 (85%) |
| Sub-optimal (>1 cm) |
11 (16%) |
22 (15%) |
14 (12%) |
47 (14%) |
| Unknown |
1 (1%) |
1 (1%) |
2 (2%) |
4 (1%) |
|
Ascites, cases only |
|
|
|
|
| No |
39 (57%) |
65 (45%) |
76 (63%) |
180 (54%) |
| Yes |
23 (33%) |
42 (29%) |
32 (26%) |
97 (29%) |
| Unknown | 7 (10%) | 39 (27%) | 13 (11%) | 59 (18%) |
*Assayed using the Illumina Infinium HumanMethylation27 BeadChip.
^Assayed using the Illumina Infinium HumanMethylation450 BeadChip.