(A) FRA3B deletions in 2067 samples from healthy individuals are illustrated. Deletions are depicted under the genomic position. Green bars indicate recurrent deletions. Red bars indicate unique deletions. In total, 61 deletions were found in the FHIT gene. Among them, 55 deletions were not unique (green bars 2+6+47). Indicated by the red bars are the unique deletions. (B) PCR for PATRR3 region in APH-induced FRA3B deletions. Lane P, Chromosome 3 hybrid DNA (Non APH-treated); Lane M, 1kb+ladder; Lane G, mouse genomic DNA; Lane N, Negative control.