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. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Stroke. 2011 Dec 15;43(2):599–606. doi: 10.1161/STROKEAHA.111.628867

Figure 2. Schematic representation of VWF-mediated platelet adhesion and aggregation.

Figure 2

VWF that is immobilized on collagen with its A3 domain or released from endothelial Weibel-Palade (WP) bodies recruits platelets by binding with its A1 domain to platelet GPIbα. Together with fibrinogen (not shown), VWF further cross-links platelets via binding of its C1 domain to platelet GPIIb/IIIa.