Skip to main content
. Author manuscript; available in PMC: 2014 Jul 17.
Published in final edited form as: Stroke. 2011 Dec 15;43(2):599–606. doi: 10.1161/STROKEAHA.111.628867

Table 1. Inhibitors of VWF-mediated platelet adhesion.

A detailed description of each of these inhibitors is given in Table S1 (please see http://stroke.ahajournals.org).

Compound Description
82D6A3 Monoclonal antibody against VWF A3 domain that inhibits binding of VWF to collagen
6B4
h6B4
Fab-fragment of a monoclonal antibody against platelet GPIbα that inhibits binding of VWF to GPIb
AJvW2
AJW200
Monoclonal antibody against VWF A1 domainα that inhibits binding of VWF to GPIbα
GPG-290 Chimeric recombinant protein containing gain-of-function GPIbα fragment that binds to A1 domain thereby inhibiting binding of VWF to GPIbα
ARC1779 Aptamer against VWF A1 domain that inhibits binding of VWF to GPIbα
ALX-0081
ALX-0681
Nanobody® against VWF A1 domain that inhibits binding of VWF to GPIbα
rADAMTS13 Recombinant protein that cleaves VWF multimers by cleaving the Y1605-M1606 bond in the VWF A2 domain