Table 1. Inhibitors of VWF-mediated platelet adhesion.
A detailed description of each of these inhibitors is given in Table S1 (please see http://stroke.ahajournals.org).
| Compound | Description |
|---|---|
| 82D6A3 | Monoclonal antibody against VWF A3 domain that inhibits binding of VWF to collagen |
| 6B4 h6B4 |
Fab-fragment of a monoclonal antibody against platelet GPIbα that inhibits binding of VWF to GPIb |
| AJvW2 AJW200 |
Monoclonal antibody against VWF A1 domainα that inhibits binding of VWF to GPIbα |
| GPG-290 | Chimeric recombinant protein containing gain-of-function GPIbα fragment that binds to A1 domain thereby inhibiting binding of VWF to GPIbα |
| ARC1779 | Aptamer against VWF A1 domain that inhibits binding of VWF to GPIbα |
| ALX-0081 ALX-0681 |
Nanobody® against VWF A1 domain that inhibits binding of VWF to GPIbα |
| rADAMTS13 | Recombinant protein that cleaves VWF multimers by cleaving the Y1605-M1606 bond in the VWF A2 domain |