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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Cell Stem Cell. 2014 Jun 5;14(6):810–823. doi: 10.1016/j.stem.2014.04.014

Figure 7. PF reduce IGF-1/PKA to promote lineage-balanced hematopoietic regeneration.

Figure 7

(A) A simplified model for a partially conserved nutrient signaling PKA pathway in yeast and mammalian cells. Arrows show promotion actions and horizontal bars indicate inhibitory actions. GH, growth hormone; AC, adenylate cyclase; PKA, protein kinase A; CREB, cAMP response element-binding protein; Foxo1, Forkhead box protein O1; G9a, H3 Lys-9 methyltransferase.

(B) A simplified model for PF-induced effects on WBC and HSCs. Fasting causes a major reduction in WBCs followed by their replenishment after re-feeding, based on effects on HSCs self-renewal resulting in increased progenitor and immune cells. These effects of PF can result in reversal of chemotherapy-based immunosuppression but also in the rejuvenation of the immune cell profile in old mice.