Table 1.
Common Gene Transcript Increases Common to All Muscles
|
Accession No. |
Gene |
Mean Fold Difference |
||
|
EOM |
Diaphragm |
EDL |
||
| Immune response | ||||
| AB001382 | Osteopontin (Spp1) | 33.0 | 11.2 | 30.2 |
| NM_133298 | Glycoprotein (transmembrane) nmb (Gpnmb) | 22.0 | 6.3 | 12.4 |
| AA945643 | Chitinase 3-like 1 (RGD:620874) | 14.0 | 5.2 | 17.5 |
| BI284255 | FK506 binding protein 5 (predicted) (RGD:1309155) | 9.0 | 13.3 | 9.7 |
| AW534837 | FK506 binding protein 5 (predicted) (RGD:1309155) | 7.6 | 11.3 | 8.4 |
| BF555488 | CD163 antigen (predicted) (RGD:1310382) | 4.6 | 2.90 | 3.3 |
| NM_031832 | Lectin, galactose binding, soluble 3 (Lgals3) | 4.2 | 2.0 | 2.9 |
| NM_012580 | Heme oxygenase (decycling) 1 (Hmox1) | 3.7 | 4.5 | 3.8 |
| BF419200 | CCAAT/enhancer binding protein (C/EBP), delta (Cebpd) | 2.9 | 6.3 | 6.1 |
| NM_017020 | Interleukin 6 receptor (Il6r) | 2.8 | 3.1 | 5.2 |
| BI276554 | Transcribed locus | 2.3 | 3.0 | 3.4 |
| BI284739 | LPS-induced TNF-alpha factor (RGD:69294) | 2.3 | 2.0 | 2.1 |
| NM_080903 | Tripartite motif-containing 63 (Trim63) | 2.2 | 5.3 | 4.5 |
| NM_013154 | CCAAT/enhancer binding protein (C/EBP), delta (Cebpd) | 2.1 | 5.7 | 6.5 |
| AB025017 | Zinc finger protein 36 (Zfp36) | 2.0 | 3.2 | 4.4 |
| Metabolism | ||||
| NM_053551 | Pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4) | 4.8 | 5.3 | 9.0 |
| M29853 | Cytochrome P450, family 4, subfamily b, polypeptide 1 (Cyp4b1) | 4.0 | 2.5 | 2.1 |
| U92069 | Uncoupling protein 3 (Ucp3) | 3.6 | 3.8 | 3.2 |
| BI274605 | Uncoupling protein 3 (Ucp3) | 3.5 | 4.1 | 3.5 |
| NM_031544 | Adenosine monophosphate deaminase 3 (Ampd3) | 3.1 | 3.9 | 15.6 |
| NM_053433 | Flavin containing monooxygenase 3 (RGD:619761) | 3.0 | 4.0 | 3.7 |
| BI279069 | Diacylglycerol O-acyltransferase homolog 2 (mouse) (Dgat2) | 2.4 | 3.1 | 2.5 |
| NM_012792 | Flavin containing monooxygenase 1 (Fmo1) | 2.3 | 2.1 | 2.4 |
| NM_017154 | Xanthine dehydrogenase (Xdh) | 2.1 | 2.1 | 2.5 |
| AF394783 | Sulfotransferase family 1A, phenol-preferring, member 1 (Sult1a1) | 2.0 | 2.4 | 2.3 |
| NM_133521 | F-box only protein 32 (Fbxo32) | 2.0 | 3.6 | 4.8 |
| Response to stress/stimulus | ||||
| AB001382 | Osteopontin (Spp1) | 33.0 | 11.2 | 30.2 |
| AF411318 | Metallothionein (Mt1a) | 26.2 | 32.1 | 64.7 |
| AA849895 | Ankyrin repeat domain 2 (stretch responsive muscle) (predicted) (RGD:1305104) | 8.1 | 5.4 | 5.2 |
| NM_024127 | Growth arrest and DNA-damage-inducible 45 alpha (Gadd45a) | 4.9 | 4.2 | 8.1 |
| NM_080906 | DNA-damage-inducible transcript 4 (Ddit4) | 4.3 | 12.1 | 10.6 |
| NM_012580 | Heme oxygenase (decycling) 1 (Hmox1) | 3.7 | 4.5 | 3.8 |
| U92069 | Uncoupling protein 3 (Ucp3) | 3.6 | 3.8 | 3.2 |
| U24174 | Cyclin-dependent kinase inhibitor 1A (Cdkn1a) | 3.4 | 4.1 | 15.8 |
| AI406908 | Similar to arsenite inducible RNA associated protein (predicted) (RGD1310991_predicted) | 3.0 | 4.7 | 7.0 |
| AI169756 | Similar to Mitogen-inducible gene 6 protein homolog (Mig-6) (Gene 33 polypeptide) | 2.7 | 5.0 | 8.4 |
| AB025017 | Zinc finger protein 36 (Zfp36) | 2.0 | 3.2 | 4.4 |
| Transcription factor | ||||
| NM_013220 | Ankyrin repeat domain 1 (cardiac muscle) (Ankrd1) | 65.5 | 31.3 | 20.7 |
| NM_017325 | Runt related transcription factor 1 (Runx1) | 8.0 | 4.1 | 6.8 |
| BM392224 | TG interacting factor (predicted) (RGD:1310517) | 3.4 | 5.2 | 9.7 |
| BF419200 | CCAAT/enhancer binding protein (C/EBP), delta (Cebpd) | 2.9 | 6.3 | 6.1 |
| AI411375 | V-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (Ets2) | 2.5 | 2.4 | 2.8 |
| NM_080903 | Tripartite motif-containing 63 (Trim63) | 2.2 | 5.3 | 4.5 |
| NM_013154 | CCAAT/enhancer binding protein (C/EBP), delta (Cebpd) | 2.1 | 5.7 | 6.5 |
| AB025017 | Zinc finger protein 36 (Zfp36) | 2.0 | 3.2 | 4.4 |
| Cell adhesion/migration | ||||
| AB001382 | Osteopontin (Spp1) | 33.0 | 11.0 | 30.0 |
| AA818262 | Angiopoietin-like protein 4 (Angptl4) | 12.5 | 13 | 17.3 |
| AI548856 | Poliovirus receptor (PVR) | 8.5 | 5.9 | 11.2 |
| NM_031832 | Lectin, galactose binding, soluble 3 (Lgals3) | 4.2 | 2.0 | 2.9 |
| Muscle | ||||
| NM_013220 | Ankyrin repeat domain 1 (cardiac muscle) (Ankrd1) | 65.5 | 31.3 | 20.7 |
| NM_017325 | Runt related transcription factor 1 (Runx1) | 8.0 | 4.1 | 6.8 |
| AI411375 | V-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (Ets2) | 2.5 | 2.4 | 2.8 |
| NM_133521 | F-box only protein 32 (Fbxo32) | 2.0 | 3.6 | 4.8 |
| Regeneration | ||||
| NM_013220 | Ankyrin repeat domain 1 (cardiac muscle) (Ankrd1) | 65.5 | 31.3 | 20.7 |
| AB001382 | Osteopontin (Spp1) | 33.0 | 11.2 | 30.2 |
| NM_012792 | Flavin containing monooxygenase 1 (Fmo1) | 2.3 | 2.1 | 2.4 |
| Cell growth/maintenance | ||||
| BI288701 | B-cell translocation gene 2, anti-proliferative (Btg2) | 3.5 | 2.1 | 3.6 |
| U24174 | Cyclin-dependent kinase inhibitor 1A (Cdkn1a) | 3.4 | 4.1 | 15.8 |
| AI179988 | Ectodermal-neural cortex 1 (RGD:1303152) | 2.1 | 4.1 | 5.3 |
| Cell-cell signaling/signal transduction | ||||
| NM_133298 | Glycoprotein (transmembrane) nmb (Gpnmb) | 22.0 | 6.3 | 12.4 |
| NM_053551 | Pyruvate dehydrogenase kinase, isoenzyme 4 (Pdk4) | 4.8 | 5.3 | 9.0 |
| NM_053338 | Ras-related associated with diabetes (Rrad) | 2.1 | 3.6 | 28.6 |
| Cell death/apoptosis | ||||
| NM_024127 | Growth arrest and DNA-damage-inducible 45 alpha (Gadd45a) | 4.9 | 4.2 | 8.1 |
| NM_012580 | Heme oxygenase (decycling) 1 (Hmox1) | 3.7 | 4.5 | 3.8 |
| Protein synthesis/modification | ||||
| None | ||||
| Receptor/ion channel | ||||
| None | ||||
| Other | ||||
| AI010427 | Ultraviolet B radiation-activated UV96 mRNA, partial sequence | 2.3 | 3.4 | 10.8 |
| NM_053819 | Tissue inhibitor of metalloproteinase 1 (Timp1) | 23.2 | 6.0 | 8.5 |
| Unclassified | ||||
| None | ||||
| EST | ||||
| BM383531 | Transcribed locus | 25.2 | 30.8 | 31.4 |
| BI274903 | Similar to RIKEN cDNA 2310057H16 (predicted) (RGD1305887_predicted) | 6.7 | 2.9 | 9.8 |
| BI294706 | Similar to MS4A6B protein (MGC94557) | 5.3 | 2.0 | 2.3 |
| AA859079 | Transcribed locus | 4.6 | 5.4 | 4.8 |
| BM385061 | Transcribed locus | 3.9 | 2.4 | 3.7 |
| AA956555 | Transcribed locus, strongly similar to XP_232342.2 similar to macrophage hemoglobin scavenger receptor CD163 precursor (Rattus norvegicus) | 3.6 | 2.8 | 3.0 |
| BG371620 | Transcribed locus | 3.1 | 2.4 | 2.5 |
| AA850715 | Transcribed locus | 2.9 | 2.4 | 3.0 |
| AI170665 | Transcribed locus | 2.9 | 4.3 | 2.2 |
| BI278547 | Hypothetical LOC300027 (LOC300027) | 2.9 | 2.1 | 2.1 |
| AI172302 | Transcribed locus | 2.9 | 2.6 | 6.9 |
| BF565188 | Transcribed locus | 2.7 | 2.2 | 2.4 |
| BF396512 | Transcribed locus | 2.7 | 3.6 | 3.1 |
| AA925542 | Transcribed locus | 2.5 | 2.7 | 3.7 |
| BF565188 | Transcribed locus | 2.2 | 2.2 | 2.4 |
| BE115141 | Transcribed locus | 2.1 | 2.2 | 2.3 |
| BI282296 | Transcribed locus | 2.1 | 2.2 | 2.0 |
| AI045724 | Transcribed locus | 2.1 | 3.5 | 4.1 |
| AI412174 | Similar to hypothetical protein MGC34760 (MGC94799) | 2.1 | 3.0 | 3.4 |