FIGURE 6.

β-catenin localization is similar in intestinal tissue from Apc^Min/+;RonTK^+/+ and Apc^Min/+;RonTK^−/− mice. Tissues from three month-old Apc^Min/+;RonTK^+/+ and Apc^Min/+;RonTK^−/− mice were analyzed for β-catenin localization by immunohistochemistry using an anti-β-catenin antibody (brown). Non-transformed epithelium demonstrates predominantly membranous staining (arrows), and adenomas exhibit intense nuclear (arrows) and cytosolic staining in the small intestine and colon from both genotypes. 400X magnification. Scale bar; 50 μm