Figure 2.
Incubation With Forodesine (Foro) and Deoxyguanosine (dGuo) Promoted the Accumulation of Deoxyguanosine Triphosphate (dGTP) but not [3H] Deoxyadenosine Triphosphate (dATP) in Pediatric B-Cell Acute Lymphoblastic Leukemia (B-ALL) Lymphoblasts. Leukemic Blast Cells Isolated From Peripheral Blood Were Incubated With Forodesine (2 µM) and dGuo (20 µM) for 24 Hours (n = 9) (A) or for 48 Hours (n = 5) (B). The Cells Were Extracted With 60% Methanol, and the Intracellular Accumulation of dGTP (A and B) and dATP (n = 5; 24 hours) (C) was Measured by DNA Polymerase Assay as Described in the Patients and Methods Section
Abbreviation: Con = control.