Table 5. Two-year MRI scan features of CHIKV-related white matter injury in eight children with perinatal mother-to-child Chikungunya virus infection, CHIMERE cohort, Reunion Island, 2008.

Child	Initiation presentation	Age (mo)	GDQ	HC (SD)*	WM areas	Demyelination	Cavitations	Gliosis	Spectroscopy
n°1	Encephalopathy	25.9	69	−1.0	Diffuse, CC	VC	VC	OVc	Normal
n°2	Encephalopathy	24.4	84	−0.3	Diffuse	VC, OvC	Absent	Absent	Normal
n°3	Encephalopathy	20.3	74	−2.2	Diffuse, CC	VC, OvC	Absent	Absent	↓ NAA
n°4	Encephalopathy	20.2	77	−2.7	Diffuse, CC	VC, OvC	Absent	Absent	↓ NAA
n°5	Prostration	20.1	79	−0.5	Normal	Absent	Absent	Absent	Normal
n°6	Encephalopathy	20.2	NA	−3.2	Diffuse, CC	VC	VC	Absent	↓ NAA
n°7	Prostration	15.8	101	+0.1	Normal	Absent	Absent	Absent	Normal
n°8	Prostration	22.4	96	−0.1	Normal	Absent	Absent	Absent	Normal

Age at neuropsychological evaluation (months); GDQ: global development quotient; HC:

*head circumference is corrected for 24 months of postnatal age;

SD: standard deviation; WM: white matter; NA: not assessed. Diffuse includes frontal plus two or more lobes; CC: corpus callosum ; OC: ovale centrum ; VC: ventricular crossroads.

↓NAA : reduction of N-acetyl-aspartate peak indicative of white matter hypometabolism or axonal loss;