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. 2014 Jul 17;10(7):e1004490. doi: 10.1371/journal.pgen.1004490

Figure 6. SIRT1 overexpression in skeletal muscle of WT and mdx mice induces the expression of neuromuscular junction genes and utrophin.

Figure 6

(A) Western blot in tissue protein homogenates prepared from gastrocnemius muscles of mdx and mdx mice crossed to Tg-4140 (mdx;TG) (B) Body weight, gastrocnemius muscle weight (of both hindlimbs) and muscle/body weight ratio of WT, Tg-4140, mdx, and mdx;Tg-4140 mice at 10–14 weeks of age (n = 5–10). (C–J) Relative mRNA levels of PGC-1α, utrophin, acetylcholine receptor (AchR) subunits α, δ, ε, and Musk, Erbb1, and Raspn in gastrocnemius muscle of WT, Tg-4140, mdx, and mdx;Tg-4140 mice (n = 3–5). Data are expressed as mean +/− s.e.m. *p<0.05, ** p<0.01, ***p<0.001 by two-tailed unpaired Student's t test.