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. 2014 Jul 17;9(7):e100152. doi: 10.1371/journal.pone.0100152

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© 2014 Tóth et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The effect of methylglyoxal on the resistance of human brain endothelial cells (hCMEC/D3) after 4-hours treatment (A). Protective effect of 3 mM edaravone (MG + E;) and 2 mM aminoguanidine (MG + AG) on methylglyoxal (MG, 600 µM) induced changes in the resistance of cell layers (4 hours co-treatment), and effect of 3 mM edaravone (E) and 2 mM aminoguanidine (AG) alone (B). TEER values are expressed as percentage of control (C). Values presented are means ± SD, n = 4. Statistical analysis: ANOVA followed by Dunnett test. Statistically significant differences (p<0.05) from the control group (#) and from the methylglyoxal treated group (*) are indicated.