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. 2014 Jul 17;9(7):e100152. doi: 10.1371/journal.pone.0100152

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© 2014 Tóth et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Dose-dependent effect of methylglyoxal-induced changes in the permeability of human brain endothelial cells (hCMEC/D3) for FITC-dextran (4.4 kDa) (A) and Evans blue labelled albumin (65 kDa) after 4 hours treatment (B). Protective effect of 3 mM edaravone (MG + E;) and 2 mM aminoguanidine (MG + AG) on methylglyoxal-induced (MG, 600 µM) changes in the permeability for FITC-dextran (4.4 kDa) (C) and Evans blue labelled albumin (D), when co-treated for 4 hours. Effect of 3 mM edaravone (E) and 2 mM aminoguanidine (AG) alone (C, D). Papp, apparent permeability coefficient expressed as a percentage of control (C). Values presented are means ± SD, n = 4. Statistical analysis: ANOVA followed by Dunnett test. Statistically significant differences (p<0.05) from the control group (#) and from the methylglyoxal treated group (*) are indicated.