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. 2014 Jul 17;9(7):e102641. doi: 10.1371/journal.pone.0102641

Figure 3. Dy105 inhibits both SMS1 and SMS2 activity.

Figure 3

SMS activity was measured as described under “Materials and methods”. Homogenate of SMS1 KO mouse liver (200 µg of total protein) was used for Dy105-mediated SMS2 inhibition (A). Homogenate of SMS2 KO mouse liver (200 µg of total protein) was used for Dy105-mediated SMS1 inhibition (B). Wild type mice were injected (i.v.) with Dy105 (1.2 mg/kg), then the liver SMS activity was measured (C) and quantitation was displayed (D). Values are Mean ± SD., n = 4, *P<0.01.