Table 3.

Characteristic of Gaucher disease type 1 patients, GBA1 heterozygotes, and non-carriers

	Parkinsonism	No parkinsonism	p values
Gaucher disease type 1	n=7	n=74
Women, n (%)	6 (85.7)	42 (56.8)	0.23
Age of onset of parkinsonism, y	41 (40, 65)	-
Age at ascertainment, y	63 (42, 72)	47 (42, 54)	0.03
Ascertained at age >60, n (%)	5 (71.4)	8 (10.8)	0.001
Ascertained family member with parkinsonism, n (%)	3 (42.9)	19 (25.7)	0.38
Age GD diagnosis, y	47 (31,60)	32 (21, 42)	0.02
GD treatment, n (%)	3 (42.9)	82 (78.4)	0.06
Age GD treatment, y	54 (33,65)	40 (34,47)	0.28
GBA1 heterozygotes	n=18	n=189
Women, n (%)	10 (55.6)	87 (46.0)	0.44
Age of onset of parkinsonism, y	62.5 (55, 67)	-
Age at ascertainment, y	67.5 (60, 72)	50 (41, 68)	0.006
Ascertained at age >60, n (%)	13 (72.2)	72 (38.1)	0.005
Ascertained family member with parkinsonism, n (%)	8 (44.4)	46 (24.3)	0.09
Genotype, n (%)			0.006*
N370S	3 (16.7)	96 (50.8)
non-N370S	15 (83.3)	93 (49.2)
Non-carriers	n=1	n=44
Women	1	21 (47.7)
Age of onset of parkinsonism, y	63	-
Age at ascertainment, y	65	53 (40, 62)
Ascertained at age >60, n (%)	1	13 (29.5)
Ascertained family member with parkinsonism, n (%)	0	3 (6.8)

Years are reported as medians with interquartile ranges unless otherwise specified

^*p value is for the 2×2 chi-squared test