Table 5.
Significant adjusted associations between cytokine genotype and fatigue group (n=223)
| Gene | SNP | Model | OR | 95% CI | p | ΔR2 | Total R2 | Full models |
|---|---|---|---|---|---|---|---|---|
| ILIB | rs1071676 | A | 1.82 | 1.01, 3.30 | .048 | .013 | .126 | χ2=39.0, p<.001 |
| African-Americans: | 1.68 | 0.58, 4.90 | .339 | .008 | .091 | χ2=9.84, p=.132 | ||
| Caucasians: | 1.60 | 0.64, 4.02 | .318 | .009 | .030 | χ2=3.36, p=.644 | ||
| Females: | 1.39 | 0.34, 5.67 | .649 | .003 | .282 | χ2=21.3, p=.002 | ||
| Males: | 2.14 | 1.01, 4.54 | .048 | .020 | .074 | χ2=15.2, p=.019 | ||
| ILIB | rs1143627 | R | 0.49 | 0.25, 0.99 | .048 | .013 | .126 | χ2=39.0, p<.001 |
| African-Americans: | 0.48 | 0.16, 1.46 | .196 | .016 | .099 | χ2=10.7, p=.099 | ||
| Caucasians: | 0.73 | 0.20, 2.63 | .631 | .002 | .023 | χ2=2.57, p=.767 | ||
| Females: | 0.32 | 0.05, 2.24 | .250 | .020 | .299 | χ2=22.6, p=.001 | ||
| Males: | 0.65 | 0.29, 1.45 | .295 | .005 | .059 | χ2=12.2, p=.058 | ||
| IL4 | rs2243274 | D | 0.43 | 0.22, 0.87 | .018 | .018 | .131 | χ2=40.5, p<.001 |
| African-Americans: | 0.34 | 0.09, 1.26 | .107 | .024 | .107 | χ2=11.5, p=.073 | ||
| Caucasians: | 0.42 | 0.14, 1.22 | .110 | .023 | .044 | χ2=4.90, p=.428 | ||
| Females: | 0.54 | 0.10, 2.81 | .461 | .007 | .287 | χ2=21.6, p=.001 | ||
| Males: | 0.34 | 0.15, 0.79 | .012 | .032 | .085 | χ2=17.6, p=.007 | ||
| TNFA | rs1800683 | A | 1.55 | 1.01, 2.40 | .047 | .013 | .125 | χ2=38.3, p<.001 |
| African-Americans: | 2.16 | 1.01, 4.62 | .048 | .040 | .124 | χ2=13.3, p=.039 | ||
| Caucasians: | 1.40 | 0.68, 2.87 | .361 | .008 | .029 | χ2=3.19, p=.671 | ||
| Females: | 2.88 | 0.94, 8.85 | .065 | .053 | .333 | χ2=25.1, p<.001 | ||
| Males: | 1.14 | 0.67, 1.91 | .633 | .001 | .052 | χ2=10.5, p=.104 | ||
| TNFA | rs1041981 | D | 1.96 | 1.02, 3.77 | .043 | .014 | .127 | χ2=387, p<.001 |
| African-Americans: | 3.94 | 0.81, 19.2 | .090 | .034 | .121 | χ2=13.0, p=.044 | ||
| Caucasians: | 1.61 | 0.63, 4.11 | .320 | .009 | .029 | χ2=3.18, p=.673 | ||
| Females: | 5.09 | 0.70, 36.8 | .107 | .044 | .323 | χ2=24.4, p<.001 | ||
| Males: | 1.42 | 0.67, 3.01 | .365 | .004 | .055 | χ2=10.9, p=.090 | ||
Notes. Models predict membership in the high fatigue group, with the low fatigue group serving as the reference. All models adjusted for genomic estimates of ancestry. In addition, the overall models also adjusted for self-reported race/ethnicity and gender, while the race-specific models also adjusted for gender, and the gender-specific models also adjusted for self-reported race/ethnicity; n=90 for analysis of the African American sub-group and n=91 for the Caucasian sub-group; n=150 for the male sub-group and n=55 for the female sub-group. A = additive model; CI = confidence interval; D = dominant model; IL = interleukin; OR = odds ratio based on dose of minor allele; R = recessive model; R2 = proportion of variance in fatigue group explained by the full model; ΔR2 = proportion of variance in fatigue group accounted for by genotype when adjusting for covariates; TNFA = tumor necrosis factor alpha.