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. Author manuscript; available in PMC: 2015 Feb 1.
Published in final edited form as: J Invest Dermatol. 2014 Mar 11;134(8):2086–2096. doi: 10.1038/jid.2014.139

Figure 5. Decreased wavefront velocity in aging mouse skin revealed by the excitable medium model.

Figure 5

a-d. Wavefront velocity decreases in an excitable medium description of the HF cycle. Plots of a. wavefront velocity, u, vs inhibitor production rate, J. b. wavefront velocity, u, vs activator production rate, α1. c. Cycling times vs inhibitor production rate, J. d. Cycling times vs activator activation rate α1.

Time spent by an individual follicle in propagating anagen (P), autonomous anagen (A), refractory telogen (R) and competent telogen (C).

e. Summary. Epidermal hair stem cell activation is regulated by intra-follicular and extra-follicular dermal activators / inhibitors. Dermal macro-environmental inhibitor levels increase in aging skin. f. Extra-follicular modulators in different hair cycle stages of young and old mouse skin. In old mice, decreased activators and increased inhibitors shorten the P phase and lengthen the R phase.

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