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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Cancer Res. 2014 May 28;74(14):3890–3901. doi: 10.1158/0008-5472.CAN-13-3694

Figure 1.

Figure 1

Selenium supplementation negatively affects leukemia development in a murine CML model. HSCs were transduced with MSCV expressing either GFP alone (control) or BCR-ABL(GFP) followed by transplantation into mice maintained on Se-A or Se-S diets. A, effect of dietary selenium on splenomegaly in CML mice. B, WBC in peripheral blood of CML mice. Range of normal levels of WBC in mice is indicated by dotted lines. Red and blue lines indicate upper and lower limits of normal levels, respectively. C, LSCs (as a % of total number of cells) in the spleen and bone marrow of mice, respectively. All data shown are mean ± s.e.m. of n= 6 per diet group. * p<0.05. D, TUNEL assay of the splenic sections (i–iv) from BCR-ABL+LSC transplanted mice on Se-D, Se-A, or Se-S diets; untransplanted Se-S splenic section used as a negative control. Representative images with TUNEL positive staining is shown. Total area of TUNEL+ staining is shown below each panel.