Table 1.
Indicated in the tables are the number of observations per condition and the behavioral testing measures (means ± s.e.m. for each) of rats that had infusions of antisense oligodeoxynucleotides (AS-ODNs) or vehicle (control) to the midbrain ventral tegmental area (VTA).
| Hormone Condition | Condition | |||||||
|---|---|---|---|---|---|---|---|---|
| Vehicle | Estradiol | |||||||
| Intra-VTA AS-ODN | Control | PXR AS-ODN | Control | PXR AS-ODN | ||||
| Intra-VTA infusion | β-cyclodextrin | 3α,5α-THP | β-cyclodextrin | 3α,5α-THP | β-cyclodextrin | 3α,5α-THP | β-cyclodextrin | 3α,5α-THP |
| N | 20 | 20 | 13 | 18 | 15 | 19 | 16 | 20 |
| Total Open Field Entries | 246.9 ± 19.5 | 261.5 ± 32.8 | 263.8 ± 37.5 | 238.0 ± 17.2 | 219.1 ± 22.9 | 218.5 ± 18.9 | 254.5 ± 24.3 | 251.1 ± 31.6 |
| Central Open Field Entries | 105.6 ± 15.9 | 106.1 ± 23.8 | 118.1 ± 26.8 | 86.5 ± 15.8 | 65.2 ± 17.9 | 64.0 ± 16.5 | 89.3 ± 18.0 | 97.4 ± 22.4 |
| Inner 8 Open Field Entries | 31.5 ± 6.2 | 28.2 ± 8.1 | 35.7 ± 9.9 | 18.2 ± 4.0 | 17.3 ± 6.8 | 17.6 ± 6.4 | 31.6 ± 7.1 | 25.7 ± 8.1 |
| Open Arm Time (secs) | 20.1 ± 5.4 | 17.2 ± 5.8 | 11.4 ± 3.5 | 22.4 ± 6.8 | 31.5 ± 15.1 | 7.4 ± 2.6 | 20.1 ± 4.8 | 26.2 ± 7.7 |
| Total time Spent Interacting (secs) | 80.6 ± 8.5 | 80.7 ± 4.9 | 73.8 ± 6.7 | 75.2 ± 5.2 | 68.9 ± 8.7 | 76.8 ± 6.7 | 73.6 ± 8.9 | 78.7 ± 9.6 |
| Lordosis Ratings (scale 0–3) | 0.01 ± 0.01 | 0.1 ± 0.1 | 0.0 ± 0.0 | 0.1 ± 0.1 | 0.6 ± 0.2^ | 1.0 ± 0.1^+ | 0.2 ± 0.5^ | 0.9 ± 0.2+ |
| Proceptivity Quotients (%) | 0.0 ± 0.0 | 0.09 ± 0.01 | 0.0 ± 0.0 | 0.0 ± 0.0 | 24.3 ± 7.9^ | 32.6 ± 8.7^ | 4.7 ± 2.3^* | 22.7 ± 6.7^* |
| Aggression Quotients (%) | 31.1 ± 5.8 | 16.6 ± 4.1 | 31.7 ± 5.8* | 28.9 ± 6.1* | 23.4 ± 7.2 | 13.3 ± 4.2 | 30.1 ± 7.8* | 26.5 ± 6.1* |
^
indicates a main effect of estradiol condition (P<0.05). + indicates a main effect of 3α,5α-THP condition (P<0.05).
*
indicates a main effect of PXR AS-ODN condition (P<0.05).