Table 3.
Comparison of Interference, and Irritable Bowel Syndrome (IBS) and Psychological Distress Symptoms in IBS Subjects with Lower and Higher PBMCa IL-10 Production
| Lower (IL-10< 250pg/ml) (n = 81) Mean (SD) |
Higher (IL-10> 250pg/ml) (n = 22) Mean (SD) |
P value | |
|---|---|---|---|
| IBS symptoms interfered withb | |||
| Daily activities | 40.6 (29.9)* | 60.7 (27.2) | .005 |
| Work | 40.3 (30.8) | 54.1 (29.6) | .077 |
| IBS symptoms (daily diary)c | |||
| Composite IBS symptom score | 56.0 (21.1) | 71.0 (19.0) | .003 |
| Abdominal pain/discomfort | 73.2 (26.8) | 89.1 (15.3) | .009 |
| IBS subtypes (Rome III criteria) | |||
| Undetermined | 2 (20) | 1 (4) | NS |
| Constipation | 20 (25) | 5 (23) | NS |
| Diarrhea | 50 (62) | 10 (46) | NS |
| Mixed | 9(11) | 6 (27) | NS |
| Psychological distress symptoms (daily diary)c | |||
| Anxiety | 50.5 (31.3) | 51.0 (32.0) | NS |
| Depression | 30.7 (31.7) | 33.3 (30.4) | NS |
| Psychological symptoms (BSI) | |||
| Global Severity Index | 0.49 (0.42) | 0.74 (0.53) | .020 |
| Anxiety | 0.63 (0.65) | 0.92 (0.85) | .093 |
| Depression | 0.48 (0.56) | 0.68 (0.67) | .155 |
a
PBMC = peripheral blood mononuclear cell
b
percent of days IBS interfered activities (≥ some) ± standard deviation
c
percent of days symptom reported (≥ mild) ± standard deviation
BSI = Brief Symptom Inventory
NS = P > .20
Controlling for age and sex did not affect the analyses