Table 4.
Increased Lactulose/Mannitol Ratio and/or PBMCa IL-10 Production and Life Interference, and Irritable Bowel Syndrome and Psychological Distress Symptoms
| Neither n = 56 Mean (SD) |
Either or Both n = 35 Mean (SD) |
P | |
|---|---|---|---|
| IBS symptoms interfered withb | |||
| Daily activities | 37.0 (28.7) | 60.2 (29.0) | .000 |
| Work | 36.7 (30.3) | 56.6 (30.3) | .004 |
| IBS Symptoms (daily diary)c | |||
| Composite IBS symptom score | 53.9 (22.2) | 67.5 (18.5) | .003 |
| Abdominal pain/discomfort | 70.1 (27.4) | 86.3 (16.3) | .002 |
| IBS subtypes (Rome III criteria) | .045 | ||
| Undetermined | 1 (2) | 2 (6) | |
| Constipation | 6 (11) | 2 (6) | |
| Diarrhea | 25 (45) | 7 (20) | |
| Mixed | 24 (433) | 24 (69) | |
| Psychological distress symptoms (daily diary)c | |||
| Anxiety | 48.8 (31.1) | 52.3 (32.4) | .549 |
| Depression | 31.1 (30.9) | 33.2 (31.1) | .754 |
| Psychological distress (BSI) | |||
| Global severity index | .47 (.41) | .68 (.53) | .040 |
| Anxiety | .57 (.65) | .86 (.80) | .065 |
| Depression | .47 (.55) | .63 (.65) | NS |
a
PBMC = peripheral blood mononuclear cell
b
percent of days IBS interfered activities (≥ some)
c
percent of days symptom reported (≥ mild) ± standard deviation
BSI = Brief Symptom Inventory
NS = P > .20
Controlling for age and sex did not affect the analyses