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. 2014 Apr 27;5(10):3246–3260. doi: 10.18632/oncotarget.1922

Figure 11. MFP increased the amounts of PEG-LD or Nab-paclitaxel in tumors with higher levels of PRA than PRB.

Figure 11

A. 59-2-HI tumors were transplanted in BALB/c-GFP mice and were treated or not with MFP as described in Figure 9. PEG-LD (18 mg/kg) were injected iv and after 24 h tumors were excised and processed for confocal microscopy studies. The red staining corresponds to the doxorubicin autofluorescence. Notice the red staining in stromal cells (orange; fill arrow) and in epithelial tumor cells nearby the stromal cells; top bar = 120 μm, bottom bar = 30 μm; B. C4-2-HI tumors were similarly treated and no differences in doxorubicin content were observed between treated and untreated tumors; bar = 120 μm. C. Tumors growing in nude mice were treated with MFP as described above and Nab-paclitaxel (60 mg/kg) was injected iv. After 24 h tumors were excised and processed for IF studies. An anti human albumin antibody and a FITC-coupled secondary antibody (green) were used. PI was used for nuclear counterstaining. No staining was observed in negative controls (treated without primary antibodies or in untreated tumors); bar = 120 μm *: p<0.05; **: p<0.01 and ***: p<0.001.