Figure 5. Effect of Nab-paclitaxel on tumor growth.

C4-2-HI tumors were transplanted into nude mice and treated with 60 or 30 mg/kg Nab-paclitaxel as described in Materials and Methods. Tumors regressed with both Nab-paclitaxel doses. Albumin alone increased tumor growth. The histological images of tumors 28 days after treatment initiation are shown. Control tumors are composed by undifferentiated cells growing as solid sheets. Treated tumors show remaining tumor nests surrounded by stromal tissue; bar = 100 μm. Tumors regressed almost completely with both Nab-paclitaxel doses, and started to grow again 10 days after the last Nab-paclitaxel dose. ***: p<0.001 experimental vs. both controls; p<0.05 control group vs. control with albumin.