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. 2014 Apr 27;5(10):3246–3260. doi: 10.18632/oncotarget.1922

Figure 6. MFP improves the therapeutic effects of Nab-paclitaxel only in mammary carcinomas showing higher levels of PRA than PRB.

Figure 6

A. left: nude mice with palpable C4-HI tumors were treated as explained in Materials and Methods with Nab-paclitaxel (30 mg/kg), MFP, or both treatments (n=6/group). MFP induced an inhibitory effect on tumor growth that was greater when combined with Nab-paclitaxel. ***: p<0.001 experimental vs. control; a vs. b or c: p<0.001. Right: Representative images of tumors excised 10 days after treatment initiation. Nab-paclitaxel induced an early increase in aberrant cells with multinucleated pleomorphic nuclei showing partially condensed chromatin. The inset shows a tetrapolar mitosis (arrow head) and a mitotic cell with chromosomal spreading (arrow). Eosinophilic cells and cells with large amounts of cytoplasm were also encountered. MFP induced differentiation. In (Nab-paclitaxel+MFP)-treated tumors, the combined treatment mimics the effect of antiprogestin, although a higher number of aberrant signet ring-like cells can be observed (inset). B. left: Nab-paclitaxel (15 mg/kg) inhibited the growth of C4-2-HI, and MFP did not improve the effect of Nab-paclitaxel. Right: No morphological differences were observed in C4-2-HI tumors with the combined treatments. Bar = 40 μm; inset bar = 20 μm.