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. 2014 Apr 27;5(10):3246–3260. doi: 10.18632/oncotarget.1922

Figure 7. MFP improves the therapeutic effects of PEG-LD and Nab-paclitaxel only in xenografts overexpressing PRA.

Figure 7

A. T47D-YA or T47D-YB xenografts growing with E2 in NSG mice (n=6/group) were treated with PEG-LD (0.9 mg/kg) or Nab-paclitaxel (15 mg/kg) and/or MFP (10 mg/kg/day). MFP only inhibited the growth of T47D-YA xenografts; PEG-LD was more effective in T47D-YA tumors compared to T47D-YB tumors, and the latter were more sensitive to Nab-paclitaxel than T47D-YA tumors. Improved effects with combined treatments were only observed in the T47D-YA tumors. ***: p<0.001; **: p<0.01; and *: p<0.05 (experimental vs. control). T47D-YA, top a vs. b: p<0.05; a vs. c: p<0.001; bottom: a vs. b or c: p<0.05. T47D-YB, bottom: a vs. b: p<0.05; a vs. c: p<0.001. B. Masson's trichrome staining. High levels of collagen (blue fibers) can be observed in all regressing tumors. C. CK staining. The amount of epithelial cells (CK+) in relation to the total number of cells can be observed. Few epithelial tumor cells remain after combined treatments in T47D-YA tumors. Conversely, for T47D-YB, the best therapeutic option was Nab-paclitaxel. Bar = 40 μm.