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. 2014 Apr 27;5(10):3273–3286. doi: 10.18632/oncotarget.1926

Figure 5. Neutral comet assay was performed at various time points after APE1 inhibitor exposure as indicated in methods.

Figure 5

A. Example of increased DNA damage comet ‘tail’ in PTEN-deficient HT144 compared to MeWo cells following 24 hours exposure to inhibitor-1. Significantly increased mean tail moment was observed in PTEN-deficient SkMel28, UACC62 and HT144 cells compared to MeWo cells following treatment with inhibitor-1 (B), inhibitor-2 (C), inhibitor 3 (D) and inhibitor 4 (E). Similarly, significantly increased mean tail moment was observed in PTEN knockdown (KD) MeWo cells compared to control MeWo cells treated with inhibitor-1 (F), inhibitor-2 (G), inhibitor 3 (H) and inhibitor 4 (I). ** p<0.01, *** p<0.001, compared to MeWo (PTEN-wildtype).