Fig. 2.

Marked microglia/macrophage activation in early, but not chronic subpial MS lesions. a–f Immunohistochemistry for KiM1P⁺ macrophages and microglia in SCD of chronic (autopsy) and early (biopsy) cases with MS. Representative images show KiM1P⁺ cells within early (a) and chronic (b) SCD of cortical layers I/II as well as the quantification thereof (c). Representative images show KiM1P⁺ cells in early (d) and chronic (e) SCD within cortical layer III as well as the quantification thereof (f). Black arrowheads point toward exemplary KiM1P+ cells. Insets in a, b, d and e show KiM1P⁺ cells in greater detail. Scale bars 25 μm in a, b, d, e; error bars indicate SEM. *p < 0.05