Table 2.
Forward stepwise regression models for anti-Ro
| Marker | Estimates from the multiple regression model
|
Single marker
|
||||
|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | Class | Gene | OR (95% CI) | P-value | |
| (A) Forward stepwise regression (BIC = 2826.1) | ||||||
| rs3129962 (A<G) | 2.44 (2.08–2.94) | 9.47 × 10−27 | Class III | BTNL2 | 2.32 (1.98–2.71) | 2.02 × 10 −25 |
| rs9271731 (A<G) | 1.54 (1.30–1.85) | 9.56 × 10−07 | Class II | DRB1-DQA1 | 1.27 (1.09–1.49) | 2.58 × 10 −03 |
| rs3957146 (G<A) | 0.52 (0.39–0.69) | 5.70 × 10−06 | Class II | DQB1-DQA2 | 0.38 (0.29–0.50) | 3.10 × 10 −12 |
| (B) Forward stepwise regression beginning from Thr77 DRB1 (BIC =2815.9) | ||||||
| Thr77 DRB1 | 0.49 (0.41–0.60) | 2.72 × 10−13 | Class II | DRB1 | 0.45 (0.39–0.52) | 5.26 × 10 −25 |
| rs9271731 (A<G) | 1.63 (1.37–1.95) | 4.50 × 10−08 | Class II | DRB1-DQA1 | 1.27 (1.09–1.49) | 2.58 × 10 −03 |
| rs3130781 (G<A) | 1.44 (1.22–1.71) | 1.76 × 10−05 | Class III | DPCR1 | 1.95 (1.69–2..25) | 2.19 × 10 −20 |
| HLA-DQB1*03:02 | 0.56 (0.42–0.73) | 2.49 × 10−05 | Class II | DQA1 | 0.42 (0.33–0.55) | 1.67 × 10 −10 |
| (C) Forward stepwise regression conditioning on HLA-DRB1*03:01 + HLA-DRB1*15:01 (BIC = 2829.8) | ||||||
| HLA-DRB1*03:01 | 2.22 (1.88–2.66) | 1.11 × 10−20 | Class II | DRB1 | 2.22 (1.91–2.59) | 9.29 × 10 −25 |
| HLA-DRB1*15:01 | 1.54 (1.28–1.85) | 4.11 × 10−06 | Class II | DRB1 | 1.32 (1.13–1.57) | 7.42 × 10 −04 |
| rs9275582 (A<G) | 0.61 (0.50–0.75) | 2.99 × 10−06 | Class II | DQB1-DQA2 | 0.45 (0.38–0.55) | 6.12 × 10 −16 |
| (D) Forward stepwise regression analysing HLA alleles only (BIC =2829.6) | ||||||
| HLA-DRB1*03:01 | 2.38 (2.02–2.80) | 1.21 × 10−25 | Class II | DRB1 | 2.22 (1.91–2.59) | 9.29 × 10 −25 |
| HLA-DRB1*15:01 | 1.63 (1.36–1.95) | 9.71 × 10−08 | Class II | DRB1 | 1.32 (1.13–1.57) | 7.42 × 10 −04 |
| HLA-DQB1*03:02 | 0.53 (0.41–0.70) | 4.84 × 10−06 | Class II | DQB1 | 0.42 (0.33–0.55) | 1.67 × 10 −10 |
| (E)Forward stepwise regression analysing amino acid data only (BIC =2827.2) | ||||||
| Thr77 DRB1 | 0.29 (0.24–0.36) | 4.00 × 10−32 | Class II | DRB1 | 0.45 (0.39–0.52) | 5.26 × 10 −25 |
| Leu67 DRB1 | 0.64 (0.53–0.77) | 2.81 × 10−06 | Class II | DRB1 | 1.05 (0.93–1.20) | 4.22 × 10 −01 |
| Gln96 DRB1 | 1.47 (1.23–1.76) | 2.29 × 10−05 | Class II | DRB1 | 1.29 (1.11–1.51) | 1.28 × 10 −03 |
Abbreviations: BIC, bayesian information criterion; CI, confidence interval; HLA, human leukocyte antigen; OR, odds ratio; SNP, single-nucleotide polymorphism. SNPs have their minor and major alleles noted in brackets (A<G where A is the minor allele, for example), the OR is with respect to the minor allele. For BIC see Materials and Methods.