Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 18;5:340. doi: 10.3389/fimmu.2014.00340

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2014 O’Connell, Volpi, Dobbs, Fiorini, Tsitsikov, de Boer, Barlan, Despotovic, Espinosa-Rosales, Hanson, Kanariou, Martínez-Beckerat, Mayorga-Sirera, Mejia-Carvajal, Radwan, Weiss, Pai, Lee and Notarangelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Clonal expansions and diversity of the CD4⁺ and CD8⁺ TRB repertoire. (A) The relative frequency of the 100 most abundant clones is displayed as a proportion of the total sequences for both CD4⁺ (left panel) and CD8⁺ (right panel) populations. The black line indicates the mean of the sample. (B) The degree of clonal expansion for CD4⁺ and CD8⁺ populations is displayed by plotting the cumulative percentage of unique clones (x) vs. the cumulative percentage of total sequences (y). A slope of one would indicate an even distribution of clonotypes. The dotted gray vertical line indicates 90% of cumulative unique sequences, with sequences to the right of the line corresponding to the top 10% most abundant unique clonotypes. (C) The diversity of each patient’s repertoire was determined by dividing the number of unique sequences over the total sequences for CD4⁺ and CD8⁺ populations. Bars represent mean and SE. In all panels, the same color is used to identify individual control subjects and patients.