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. 2014 Jul 18;5:340. doi: 10.3389/fimmu.2014.00340

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Copyright © 2014 O’Connell, Volpi, Dobbs, Fiorini, Tsitsikov, de Boer, Barlan, Despotovic, Espinosa-Rosales, Hanson, Kanariou, Martínez-Beckerat, Mayorga-Sirera, Mejia-Carvajal, Radwan, Weiss, Pai, Lee and Notarangelo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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J segment usage is skewed in the TRB repertoire of CD8⁺ cells in WAS patients. (A) Donut graphs compare the representative frequencies of TRBJ segment usage for total (inner ring) and unique (outer ring) sequences for controls and WAS patients (see also inset key). (B) Direct comparison of J segment usage between WAS patients and controls.