Table 2.
Mortality Rates and Survival for 482 HIV-Infected Adults in the Center for AIDS Research Network of Integrated Clinical Systems Cohort With Lymphoma Between 1996 and 2011, Stratified by Histology and Unmasking Immune Reconstitution Inflammatory Syndrome Case Status
| Case Status | Persons | Deaths | Person-years | Mortality Rate per 100 Person-years (95% CI) | 6-mo Survival % (95% CI) | 1-y Survival % (95% CI) | 5-y Survival % (95% CI) |
|---|---|---|---|---|---|---|---|
| All lymphoma | 482 | 229 | 1571 | 14.6 (12.8–16.6) | 70 (66–75) | 60 (55–65) | 44 (40–50) |
| IRIS | 56 | 30 | 169 | 17.7 (12.4–23.4) | 62 (50–76) | 54 (42–69) | 49 (37–64) |
| Non-IRIS | 426 | 199 | 1402 | 14.2 (12.4–16.3) | 72 (67–77) | 61 (56–67) | 44 (39–50) |
| HL | 80 | 25 | 302 | 8.3 (5.6–12.2) | 82 (73–92) | 77 (67–88) | 61 (50–75) |
| IRIS | 12 | 2 | 52 | 3.9 (1.0–15.4) | 82 (71–93) | 83 (65–100) | 83 (65–100) |
| Non-IRIS | 68 | 23 | 250 | 9.2 (6.1–13.8) | 82 (73–93) | 76 (65–89) | 57 (45–73) |
| All NHL | 402 | 204 | 1269 | 16.1 (14.0–18.4) | 68 (63–73) | 57 (51–62) | 41 (36–47) |
| IRIS | 44 | 28 | 118 | 23.9 (16.5–34.6) | 56 (43–73) | 46 (34–64) | 40 (27–58) |
| Non-IRIS | 358 | 176 | 1152 | 15.3 (13.2–17.7) | 70 (64–76) | 58 (53–65) | 42 (36–48) |
| BL | 57 | 23 | 157 | 14.6 (9.7–22.0) | 73 (61–88) | 63 (50–79) | 51 (38–68) |
| IRIS | 5 | 3 | 5 | 62.7 (20.2–194.5) | 60 (32–100) | 40 (16–99) | 40 (16–99) |
| Non-IRIS | 52 | 20 | 153 | 13.1 (8.5–20.3) | 75 (62–90) | 66 (53–82) | 53 (39–71) |
| PCNSL | 54 | 41 | 121 | 33.8 (24.9–45.9) | 38 (27–54) | 28 (18–43) | 23 (14–37) |
| IRIS | 10 | 10 | 2 | 417.6 (224.7–776.2) | 10 (2–4) | 0 (0–0) | 0 (0–0) |
| Non-IRIS | 44 | 31 | 119 | 26.1 (18.3–37.1) | 45 (32–63) | 34 (23–51) | 28 (18–44) |
| DLBCL | 205 | 101 | 692 | 14.6 (12.0–17.7) | 75 (69–83) | 64 (57–72) | 44 (37–53) |
| IRIS | 22 | 10 | 85 | 11.8 (6.3–21.9) | 72 (55–93) | 67 (50–90) | 54 (36–81) |
| Non-IRIS | 183 | 91 | 608 | 15.0 (12.2–18.4) | 76 (69–84) | 64 (56–72) | 43 (36–52) |
| Other NHL | 86 | 39 | 298 | 13.1 (9.6–17.9) | 71 (60–84) | 59 (47–73) | 44 (33–59) |
| IRIS | 7 | 5 | 24 | 19.7 (8.2–47.4) | 71 (46–100) | 57 (32–100) | 57 (32–100) |
| Non-IRIS | 79 | 34 | 273 | 12.5 (8.9–17.5) | 71(59–86) | 60 (47–75) | 43 (32–58) |
Abbreviations: BL, Burkitt lymphoma; CI, confidence interval; DLBCL, diffuse large B-cell lymphoma; HIV, human immunodeficiency virus; HL, Hodgkin lymphoma; IRIS, immune reconstitution inflammatory syndrome; NHL, non-Hodgkin lymphoma; PCNSL, primary central nervous system lymphoma.