Table 5. Prognostic factors analysis (N=241).
|
Univariate analysis | ||
|---|---|---|
| Variable | Median OS (mos) | P-value (univariate) |
| All |
11.4 |
|
|
Gender |
|
|
| Male | 11.4 | 0.460 |
| Female |
10.9 |
|
|
Age (years) |
|
|
| <75 | 13.4 | 0.006 |
| ⩾75 |
8.9 |
|
|
Asbestos exposure |
|
|
| Occupational/ environmental | 10.4 | 0.009 |
| Uncertain/not documented |
15.2 |
|
|
ECOG performance status |
|
|
| 0 | 11.3 | 0.843 |
| ⩾1 |
10.9 |
|
|
IMIG stage |
|
|
| Early (I–II) | 15.2 | 0.021 |
| Advanced (III–IV) |
9.7 |
|
|
Charlson Comorbidity Index |
|
|
| 0 | 13.1 | 0.057 |
| ⩾1 |
9.4 |
|
|
Histology |
|
|
| Epithelioid | 14.5 | <0.001 |
| Non epithelioid |
7.4 |
|
|
Pemetrexed (yes
vs
no) |
|
|
| Yes | 13.2 | <0.001 |
| No | 4.9 | |
|
Multivariate analysis | ||
|---|---|---|
| Variable | HR (CI 95%) | P-value (multivariate) |
| Age |
1.39 (1.04; 1.86) |
0.026 |
| Charlson Comorbidity Index |
1.42 (1.06; 1.91) |
0.019 |
| Histology |
2.40 (1.73; 3.34) |
<0.001 |
| Pemetrexed | 0.41 (0.29; 0.58) | <0.001 |
Abbreviations: CI=confidence interval; ECOG=Eastern Cooperative Oncology Group; HR=hazard ratio; IMIG=International Mesothelioma Interest Group; OS=overall survival.