Table 5. Adverse events of special interest with bevacizumab.

Adverse events, n (%)	Any grade	Grade 1	Grade 2	Grade 3	Grade 4
Hypertension	8 (12)	2 (3)	5 (7)	1 (1)	0
Ischaemic event	1 (1)	0	0	1 (1)	0
Angina	1 (1)	0	0	1 (1)	0
Epistaxis	9 (13)	8 (12)	1 (1)	0	0
Bleeding gums	1 (1)	1 (1)	0	0	0
Bleeding from colostomy	1 (1)	1 (1)	0	0	0
Rectal bleeding	1 (1)	1 (1)	0	0	0
Bloody stool	1 (1)	0	1 (1)	0	0
Proteinuria	8 (12)	2 (3)	5 (7)	1 (1)	0
Deep-vein thrombosis	6 (9)	0	2 (3)	4 (6)	0
Pulmonary thromboembolism	4 (6)	0	1 (1)	2 (3)	1 (1)
Gastrointestinal perforation	1 (1)	0	0	1 (1)	0