Figure 3.

ThT analysis shows that peptoid JPT1 modulates Aβ40 aggregation. JPT1 decreases lag time to Aβ40 aggregation and decreases the quantity of β-sheet aggregates formed. JPT1 was added to 20 μM Aβ40 monomer at concentrations of 0 (control), 20, 50, 100, and 200 μM, and the presence of fibrillar aggregates was detected by ThT fluorescence. Normalized fluorescence values are calculated as a percentage of the control plateau. Lag extension, or the fold change in lag time, and percent inhibition, or percentage decrease in the plateau, are shown below the graph. Parameters are expressed as mean ± SEM, n = 2. *p < 0.05; ***p < 0.0001.